Wednesday, December 28, 2011

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Source: http://twitter.com/tanman9/statuses/151370677247680512

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Tuesday, December 27, 2011

Africa's Quest for Prosperity

Op-Ed, The Guardian

December 26, 2011

Author: Calestous Juma, Professor of the Practice of International Development; Director, Science, Technology, and Globalization Project; Principal Investigator, Agricultural Innovation in Africa

Belfer Center Programs or Projects: Science, Technology, and Globalization; Science, Technology, and Public Policy

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As African economies look for growth in the future, the two key internal strategies emerging are regional integration and harnessing diasporas for funds and technical expertise

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In an implicitly apologetic headline, the Economist recently declared Africa a "hopeful continent". A decade ago its headline for a story on Sierra Leone dismissed Africa as hopeless. This message comes during a period of uncertainty for Africa's major trading partners.

The European debt crisis threatens to plunge the world into an economic downturn, the impact of which could take up to a decade to undo. China's continued demand for Africa's raw materials could also be affected by the slowing down of its exports to Europe and the US.

The prospects for continued prosperity in Africa will certainly be affected by external factors. However, internal growth dynamics are likely to shape the future of the continent in profound ways. There are two important trends to watch: expanded regional markets, and improved strategies to harness the continent's diasporas as sources of technical expertise and business networks.

The process of regional integration is probably Africa's most important innovation in governance. Africa's Regional Economic Communities (Recs) appear on the surface as convenient tools to govern an otherwise expansive continent (three times the size of the US). The Democratic Republic of the Congo (DRC) alone is the size of western Europe.

The African Development Bank has projected a 5.8% economic growth rate for 2012. This figure may be revised downwards, but countries such as Angola, Ethiopia, the DRC and Zambia will continue to record high growth rates.

The performance will be reinforced by efforts to expand internal regional trade. Three regional bodies ? the Common Market for Eastern and Southern Africa, the East African Community, and the Southern African Development Community ? have agreed to launch negotiations to create a Cape-to-Cairo grand free trade area.

The 27-nation trade pact will include a population of more than 700 million with a combined GDP of $1tr. The most critical aspect of the grand area will be investment in infrastructure (especially energy, transport, water and telecommunications).

It is projected that Africa will need to invest nearly $50bn annually over the next decade to meet its development goals. The investments, even if only partially made, will foster internal trade, generate employment and attract foreign direct investment.

The investment in fibre-optic cables illustrates the potential. In 2008, there was only one fibre-optic cable along the western coast of Africa. It operated at 5% capacity utilisation and had negligible economic impact.

Today, nearly $3.5bn has been invested in cables around the continent. These cables are dramatically lowering the cost of doing business by increasing communication speeds and slashing data transmission prices (by up to 80%). That $650m Seacom cable along the eastern coast of Africa has leveraged more than $6bn for terrestrial cables extending into the interior of the continent.

The next phase in this growth is going to be expanding mobile broadband. The GSM Association estimates that greater allocation of mobile broadband will "create up to 27m new jobs, increase GDP per capita by 5.2%, which will directly lift 40 million people out of poverty by 2025". The association estimates that spectrum expansion would also "increase gross domestic product and government tax revenues by $82bn billion and $18bn per year respectively by 2025".

The economic impact will be evident in the short-run. It is projected that Africa will have up to 240m mobile broadband connections by 2015. However, the economic gains will only be efficiently realised through regionally harmonised spectrum allocation. Such regional growth dynamics will also be realised in other areas of infrastructure investment such as energy, transport and irrigation.

Probably the most critical challenge facing Africa's quest for regional integration is the limited availability of technical and entrepreneurial capabilities. More specifically, Africa's educational systems have so far paid little attention to training in the engineering fields and related business knowledge.

This shortfall is likely to be filled by finding new ways of tapping into Africa's diasporas. It is estimated that more than 30 million Africans live in the diaspora, and they remitted nearly $40bn in 2010. The figure could exceed $60bn when informal fund transfers are included. In the past decade, African countries have been exploring ways to maximise remittances to supplement export earnings.

But attention is now shifting to diasporas as sources of expert knowledge and international business networks. This shift is reflected in foreign policy reforms designed to specifically include economic diplomacy as a key pillar in international relations. Countries that have introduced such changes in their foreign relations include Kenya and Ethiopia.

Next year will bring a number of uncertainties and challenges for fledgling African economies. However, many of the initiatives launched by the continent to deepen regional integration and tap into its diasporas will help it to weather external economic storms.

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For more information about this publication please contact the Belfer Center Communications Office at 617-495-9858.

Full text of this publication is available at:
http://www.guardian.co.uk/global-development/poverty-matters/2011/dec/26/africa-
quest-prosperity-economies-integration

For Academic Citation:

Juma, Calestous. "Africa's Quest for Prosperity." The Guardian, December 26, 2011.

Source: http://www.belfercenter.org/publication/21640/africas_quest_for_prosperity.html

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Monday, December 26, 2011

Raiders stay alive with 16-13 OT win over Chiefs

Romeo Crennel

By DAVE SKRETTA

updated 4:25 p.m. ET Dec. 24, 2011

KANSAS CITY, Mo. - Sebastian Janikowski kicked a 36-yard field goal 2:13 into overtime Saturday, giving the Oakland Raiders a 16-13 victory over Kansas City that eliminated the Chiefs from the playoff race and kept their own AFC West hopes alive.

Carson Palmer threw for 237 yards and a touchdown for the Raiders (8-7). His perfectly thrown 53-yard pass to Darrius Heyward-Bey early in overtime set up Janikowski's winning kick, allowing Oakland to avoid a second straight late-game meltdown.

Kyle Orton threw for 300 yards for Kansas City, his only touchdown pass going to Dwayne Bowe with 1:02 left in regulation to tie the game. The Raiders went three-and-out, giving Kansas City the ball back with little time on the clock, and Orton hit Bowe for 25 yards and Terrance Copper for 11 more to set up Ryan Succop for a potential winning field goal on the final play of the game.

Succop's 49-yard try was blocked by Trevor Scott to send the game to overtime.

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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More news
Tebow throws 4 INTs in loss

??Jairus Byrd and Spencer Johnson returned Tim Tebow interceptions for touchdowns on consecutive plays in the fourth quarter to help the Buffalo Bills snap a seven-game skid and seal a 40-14 win over the Denver Broncos on Saturday.

Raiders stay alive with 16-13 OT win over Chiefs

??Sebastian Janikowski kicked a 36-yard field goal 2:13 into overtime Saturday, giving the Oakland Raiders a 16-13 victory over Kansas City that eliminated the Chiefs from the playoff race and kept their own AFC West hopes alive.

Source: http://nbcsports.msnbc.com/id/45784574/ns/sports-nfl/

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Friday, December 23, 2011

Suicidal Ohio animal owner not drunk or on drugs (AP)

COLUMBUS, Ohio ? A final coroner's report shows an Ohio man who released dozens of wild animals and then killed himself had no alcohol or illegal drugs in his system.

The Columbus Dispatch reports ( http://bit.ly/saaXlR) that the findings released Wednesday also confirm that 62-year-old Terry Thompson died after he put a gun to the roof of his mouth and fired. And the report indicates he was bitten and clawed by large cats immediately after his Oct. 18 death on his property near Zanesville in eastern Ohio.

Sheriff's deputies were forced to kill 48 loose exotic animals, including bears, lions and endangered Bengal tigers.

Three leopards, two primates and a grizzly bear survived the big-game hunt and are now in the care of the Columbus zoo.

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Information from: The Columbus Dispatch, http://www.dispatch.com

Source: http://us.rd.yahoo.com/dailynews/rss/pets/*http%3A//news.yahoo.com/s/ap/20111222/ap_on_re_us/us_exotic_animals_loose_autopsy

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Previously unconnected molecular networks conspire to promote cancer

Thursday, December 22, 2011

An inflammation-promoting protein triggers deactivation of a tumor-suppressor that usually blocks cancer formation via the NOTCH signaling pathway, a team of researchers led by scientists at The University of Texas MD Anderson Cancer Center reports today in Molecular Cell.

Working in liver cancer cell lines, the team discovered a mechanism by which tumor necrosis factor alpha (TNF?) stimulates tumor formation, said senior author Mien-Chie Hung, Ph.D., professor and chair of MD Anderson's Department of Molecular and Cellular Oncology. Hung also is MD Anderson's vice president for basic research.

"We've discovered cross-talk between the TNF? inflammation and NOTCH signaling pathways, which had been known to separately promote cancer development and growth," Hung said. Liver cancer is one of several cancers, including pancreatic and breast, associated with inflammation.

Their findings have potential implications for a new class of anti-cancer drugs currently in clinical trials. "Pharmaceutical companies are developing NOTCH inhibitors," Hung said. "TNF? now presents a potential resistance mechanism that activates NOTCH signaling in a non-traditional way."

Pathways also unite in colon, lung, prostate cancers

"In addition, co-activation of these two pathways was also observed in colon, lung and prostate cancers, suggesting that the cross-talk between these two pathways may be more generally relevant," Hung said.

However, TNF? also presents an opportunity to personalize therapy, Hung said. The presence of TNF? or a separate protein that it activates called IKK alpha may serve as useful biomarkers to guide treatment.

"If a patient has only NOTCH activated, then the NOTCH inhibitor alone might work. But if TNF? or IKK? are also activated, then the NOTCH inhibitor alone might not work very well and combination therapy would be warranted," Hung said.

"We'll try this in an animal model and then go to clinical trial if it holds up," Hung said.

A path from inflammation to liver cancer

In a series of experiments, Hung and colleagues connected the following molecular cascade:

  • TNF?, a proinflammatory cytokine, signals through a cell's membrane, activating IKK?, a protein kinase that regulates other proteins by attaching phosphate groups (one phosphate atom, four oxygen atoms) to them.
  • IKK? moves into the cell nucleus, where it phosphorylatesFOXA2, a transcription factor that normally fires up the tumor suppressor NUMB.
  • NUMB usually blocks a protein called NICD, the activated portion of NOTCH1 that slips into the cell nucleus to activate genes that convert the normal cell to a malignant one.
  • But when FOXA2 is phosphorylated, it does not activate NUMB. With NUMB disabled, NOTCH1 is activated. New understanding, new targets for cancer therapy

In liver cancer (hepatocellular carcinoma) tumors, IKK?, the phosphorylated version of FOXA2 and NOTCH1 are expressed more heavily than in normal liver tissue. Expression of all three is correlated in liver cancer tumors, the team found.

The authors conclude that identifying the link between TNF? and NOTCH1 pathways provides a new starting point for understanding the molecular basis for TNF?-related tumor growth and for identifying new targets for cancer therapy.

Finding ways to inhibit FOXA2 phosphorylation or to activate NUMB would provide new options for treating and perhaps preventing cancer, Hung said.

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University of Texas M. D. Anderson Cancer Center: http://www.mdanderson.org

Thanks to University of Texas M. D. Anderson Cancer Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 27 time(s).

Source: http://www.labspaces.net/116280/Previously_unconnected_molecular_networks_conspire_to_promote_cancer

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Thursday, December 22, 2011

Personal Finance Website MyMoneyCircles.com Launched to Help ...

Foster City, CA (PRWEB) December 20, 2011

MyMoneyCircles.com, a site offering a free online personal finance boot camp program, advice from a team of advisers and a supportive community, has launched to help individuals kick-start their journey to better financial health.

MyMoneyCircles offers four critical elements for personal financial success to its visitors and program participants:


Trustworthy expert advice. Nationally recognized personal finance expert Lynnette Khalfani-Cox and a team of finance experts will answer questions from participants on consumer credit and debt, banking, mortgage and insurance products and services.
Step-by-step guidance. The sites boot camp program consists of four weekly Success Guide modules. Each Success Guide is broken into steps designed to take around 20 to 30 minutes per day for participants to complete.
Practical tools. In each Success Guide module, participants can find resources such as online comparison shopping tools for auto insurance coverage and credit card comparison tools, calculators and government help in one place.
A support community. Participants can join a community anonymously where they can share successes, challenges, advice and encouragement with others.

MyMoneyCircles offers free programs with a whole team of experts skilled at showing individuals which areas of their finances they need to shore up and how to go about doing it, said Khalfani-Cox, a respected personal finance authority and New York Times bestselling author. For anyone who would love expert help with their finances but can?t afford to hire a financial adviser, theres really no excuse not to give this a try, she said.

The free boot camp offered by MyMoneyCircles.com was created for all individuals who are serious about making positive financial changes and want to take manageable steps toward financial health.

The boot camp is designed to be simple to use and produce effective results for participants with a variety of financial goals and needs whether those goals are saving for retirement, planning ahead for college costs, getting out of debt, sticking to a budget or simply saving money.

For those who are serious about improving their financial fitness, MyMoneyCircles is the perfect way to kick off those New Year resolutions with a bang, said Khalfani-Cox. Its an action-oriented, no-excuses boot camp that works.

The MyMoneyCircles boot camp officially launches January 9, 2012, just in time to help registrants gain momentum on New Years resolutions to get their finances in order.

Individuals who visit MyMoneyCircles.com and register before January 9 will be entered in a drawing for an early bird registration prize. Five winners will be invited to participate in a free, customized financial coaching webinar with Khalfani-Cox which includes a live Q&A session. In addition, fans of MyMoneyCircles Facebook page and followers of its Twitter account @MyMoneyCircles will have opportunities to receive giveaways of Khalfani-Coxs books, podcasts and other prizes.

About MyMoneyCircles.com

MyMoneyCircles.com is a free online personal finance boot camp and community designed to help individuals take manageable steps to financial health. With articles, online tools, checklists, quizzes, videos and, above all, expert help, MyMoneyCircles.com offers participants the tools to save more, get out of debt and meet financial goals. MyMoneyCircles.com is a joint effort of Lynnette Khalfani-Cox and QuinStreet, Inc. Follow MyMoneyCircles on Twitter @MyMoneyCircles or visit the MyMoneyCircles Facebook page. MyMoneyCircles.com is owned and operated by QuinStreet, Inc. (NASDAQ: QNST), one of the largest Internet marketing and media companies in the world. QuinStreet is committed to providing consumers and businesses with the information they need to research, find and select the products, services and brands that best meet their needs. The company is a leader in visitor-friendly marketing practices. For more information, please visit QuinStreet.com.

About Lynnette Khalfani-Cox

Lynnette Khalfani-Cox, The Money Coach, is a personal finance expert, television and radio personality, and the author of numerous books, including the New York Times bestseller Zero Debt: The Ultimate Guide to Financial Freedom. A former Wall Street Journal reporter for CNBC, Lynnette has appeared on such national TV programs as The Oprah Winfrey Show, Dr. Phil, The Today Show and Good Morning America. She frequently appears as a guest commentator on CNN, MSNBC, ABC and FOX Business Network. Follow Lynnette on Twitter @themoneycoach or visit her free financial advice blog at AskTheMoneyCoach.com.

Press Contact

Andrew Heilman

775-784-3842

pr(at)mymoneycircles(dot)com

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Source: http://www.carriagewerks.com/?p=61

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